Associations between cytokine gene variations and self-reported sleep disturbance in women following breast cancer surgery.

ABSTRACT:

Purpose of the research

To attempt to replicate the associations found in our previous study of patients and family caregivers between interleukin 6 (IL6) and nuclear factor kappa beta 2 (NFKB2) and sleep disturbance and to identify additional genetic associations in a larger sample of patients with breast cancer.

Methods and sample

Patients with breast cancer (n = 398) were recruited prior to surgery and followed for six months. Patients completed a self-report measure of sleep disturbance and provided a blood sample for genomic analyses. Growth mixture modeling was used to identify distinct latent classes of patients with higher and lower levels of sleep disturbance.

Key results

Patients who were younger and who had higher comorbidity and lower functional status wer

SUBMITTER: Alfaro E 

PROVIDER: S-EPMC3946647 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature