Effects of multivitamin supplement on cataract and age-related macular degeneration in a randomized trial of male physicians.

ABSTRACT:

Purpose

To test whether long-term multivitamin supplementation affects the incidence of cataract or age-related macular degeneration (AMD) in a large cohort of men.

Design

Randomized, double-blind, placebo-controlled trial.

Participants

A total of 14,641 US male physicians aged ≥ 50 years.

Intervention

Daily multivitamin or placebo.

Main outcome measures

Incident cataract and visually significant AMD responsible for a reduction in best-corrected visual acuity to 20/30 or worse based on self-reports confirmed by medical record review.

Results

During an average of 11.2 years of treatment and follow-up, a total of 1817 cases of cataract and 281 cases of visually significant AMD were confirmed. There were 872 cataracts in the multivitamin group and 94

SUBMITTER: Christen WG 

PROVIDER: S-EPMC3946650 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature