Support of a bi-faceted role of estrogen receptor β (ERβ) in ERα-positive breast cancer cells.

ABSTRACT: The expression of estrogen receptor α (ERα) in breast cancer identifies patients most likely to respond to endocrine treatment. The second ER, ERβ, is also expressed in breast tumors, but its function and therapeutic potential need further study. Although in vitro studies have established that ERβ opposes transcriptional and proliferative functions of ERα, several clinical studies report its correlation with proliferative markers and poorer prognosis. The data demonstrate that ERβ opposes ERα are primarily based on transient expression of ERβ. Here, we explored the functions of constitutively expressed ERβ in ERα-positive breast cancer lines MCF7 and T47D. We found that ERβ, under these conditions heterodimerized with ERα in the presence and absence of 17β-estradiol, and induced genome-wid

SUBMITTER: Jonsson P 

PROVIDER: S-EPMC3946733 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature