Hepatic histological findings in suspected drug-induced liver injury: systematic evaluation and clinical associations.

ABSTRACT:

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Drug-induced liver injury (DILI) is considered to be a diagnosis of exclusion. Liver biopsy may contribute to diagnostic accuracy, but the histological features of DILI and their relationship to biochemical parameters and outcomes are not well defined. We have classified the pathological pattern of liver injury and systematically evaluated histological changes in liver biopsies obtained from 249 patients with suspected DILI enrolled in the prospective, observational study conducted by the Drug Induced Liver Injury Network. Histological features were analyzed for their frequency within different clinical phenotypes of liver injury and to identify associations between clinical and laboratory findings and histological features. The most common histological patterns were acu

SUBMITTER: Kleiner DE 

PROVIDER: S-EPMC3946736 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature