Family-based association analysis of alcohol dependence criteria and severity.

ABSTRACT:

Background

Despite the high heritability of alcohol dependence (AD), the genes found to be associated with it account for only a small proportion of its total variability. The goal of this study was to identify and analyze phenotypes based on homogeneous classes of individuals to increase the power to detect genetic risk factors contributing to the risk of AD.

Methods

The 7 individual DSM-IV criteria for AD were analyzed using latent class analysis (LCA) to identify classes defined by the pattern of endorsement of the criteria. A genome-wide association study was performed in 118 extended European American families (n = 2,322 individuals) densely affected with AD to identify genes associated with AD, with each of the 7 DSM-IV criteria, and with the probability of belonging t

SUBMITTER: Wetherill L 

PROVIDER: S-EPMC3946798 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature