ALDH-1 expression levels predict response or resistance to preoperative chemoradiation in resectable esophageal cancer patients.

ABSTRACT:

Purpose

Operable thoracic esophageal/gastroesophageal junction carcinoma (EC) is often treated with chemoradiation and surgery but tumor responses are unpredictable and heterogeneous. We hypothesized that aldehyde dehydrogenase-1 (ALDH-1) could be associated with response.

Methods

The labeling indices (LIs) of ALDH-1 by immunohistochemistry in untreated tumor specimens were established in EC patients who had chemoradiation and surgery. Univariate logistic regression and 3-fold cross validation were carried out for the training (67% of patients) and validation (33%) sets. Non-clinical experiments in EC cells were performed to generate complimentary data.

Results

Of 167 EC patients analyzed, 40 (24%) had a pathologic complete response (pathCR) and 27 (16%) had an extrem

SUBMITTER: Ajani JA 

PROVIDER: S-EPMC3946849 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature