C1q binding to dengue virus decreases levels of infection and inflammatory molecules transcription in THP-1 cells.

ABSTRACT: Dengue virus infection elicits a spectrum of clinical presentations ranging from asymptomatic to severe disease. The mechanisms leading to severe dengue are not known, however it has been reported that the complement system is hyper-activated in severe dengue. Screening of complement proteins demonstrated that C1q, a pattern recognition molecule, can bind directly to dengue virus envelope protein and to whole dengue virus serotype 2. Incubation of dengue virus serotype 2 with C1q prior to infection of THP-1 cells led to decreased virus infectivity and modulation of mRNA expression of immunoregulatory molecules suggesting reduced inflammatory responses.

SUBMITTER: Douradinha B 

PROVIDER: S-EPMC3946857 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature