Gene expression and genetic variation in human atria.

ABSTRACT:

Background

The human left and right atria have different susceptibilities to develop atrial fibrillation (AF). However, the molecular events related to structural and functional changes that enhance AF susceptibility are still poorly understood.

Objective

The purpose of this study was to characterize gene expression and genetic variation in human atria.

Methods

We studied the gene expression profiles and genetic variations in 53 left atrial and 52 right atrial tissue samples collected from the Myocardial Applied Genomics Network (MAGNet) repository. The tissues were collected from heart failure patients undergoing transplantation and from unused organ donor hearts with normal ventricular function. Gene expression was profiled using the Affymetrix GeneChip Human Genome

SUBMITTER: Lin H 

PROVIDER: S-EPMC3946863 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature