Racial differences in the association of insulin-like growth factor pathway and colorectal adenoma risk.

ABSTRACT:

Purpose

Insulin resistance is believed to play an important role in the link between energy imbalance and colon carcinogenesis. Emerging evidence suggests that there are substantial racial differences in genetic and anthropometric influences on insulin-like growth factors (IGFs); however, few studies have examined racial differences in the associations of IGFs and colorectal adenoma, precursor lesions of colon cancer.

Methods

We examined the association of circulating levels of IGF-1, IGFBP-3 and IGFBP-1, and SNPs in the IGF-1 receptor (IGF1R), IGF-2 receptor (IGF2R), and insulin receptor genes with risk of adenomas in a sample of 410 incident adenoma cases and 1,070 controls from the Case Transdisciplinary Research on Energetics and Cancer (TREC) Colon Adenomas Study.

Re

SUBMITTER: Ochs-Balcom HM 

PROVIDER: S-EPMC3946890 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature