Molecular signatures of antibody responses derived from a systems biology study of five human vaccines.

ABSTRACT: Many vaccines induce protective immunity via antibodies. Systems biology approaches have been used to determine signatures that can be used to predict vaccine-induced immunity in humans, but whether there is a 'universal signature' that can be used to predict antibody responses to any vaccine is unknown. Here we did systems analyses of immune responses to the polysaccharide and conjugate vaccines against meningococcus in healthy adults, in the broader context of published studies of vaccines against yellow fever virus and influenza virus. To achieve this, we did a large-scale network integration of publicly available human blood transcriptomes and systems-scale databases in specific biological contexts and deduced a set of transcription modules in blood. Those modules revealed distinct tra

SUBMITTER: Li S 

PROVIDER: S-EPMC3946932 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature