Liver environment and HCV replication affect human T-cell phenotype and expression of inhibitory receptors.

ABSTRACT:

Background & aims

There is an unclear relationship between inhibitory receptor expression on T cells and their ability to control viral infections. Studies of human immune cells have been mostly limited to T cells from blood, which is often not the site of infection. We investigated the relationship between T-cell location, expression of inhibitory receptors, maturation, and viral control using blood and liver T cells from patients with hepatitis C virus (HCV) and other viral infections.

Methods

We analyzed 36 liver samples from HCV antibody-positive patients (30 from patients with chronic HCV infection, 5 from patients with sustained virological responses to treatment, and 1 from a patient with spontaneous clearance) with 19 paired blood samples and 51 liver samples from HC

SUBMITTER: Kroy DC 

PROVIDER: S-EPMC3946973 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature