Ontology highlight
ABSTRACT:
SUBMITTER: Gilbert MR
PROVIDER: S-EPMC3946987 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Gilbert Misty R MR Liu Yinxing Y Neltner Janna J Pu Hong H Morris Andrew A Sunkara Manjula M Pittman Thomas T Kyprianou Natasha N Horbinski Craig C
Acta neuropathologica 20131023 2
IDH1 mutations in gliomas associate with longer survival. Prooxidant and antiproliferative effects of IDH1 mutations and its D-2-hydroxyglutarate (2-HG) product have been described in vitro, but inconsistently observed. It is also unclear whether overexpression of mutant IDH1 in wild-type cells accurately phenocopies the effects of endogenous IDH1-mutations on tumor apoptosis and autophagy. Herein we investigated the effects of 2-HG and mutant IDH1 overexpression on proliferation, apoptosis, oxi ...[more]