NEDD9 depletion leads to MMP14 inactivation by TIMP2 and prevents invasion and metastasis.

ABSTRACT:

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The scaffolding protein NEDD9 is an established prometastatic marker in several cancers. Nevertheless, the molecular mechanisms of NEDD9-driven metastasis in cancers remain ill-defined. Here, using a comprehensive breast cancer tissue microarray, it was shown that increased levels of NEDD9 protein significantly correlated with the transition from carcinoma in situ to invasive carcinoma. Similarly, it was shown that NEDD9 overexpression is a hallmark of highly invasive breast cancer cells. Moreover, NEDD9 expression is crucial for the protease-dependent mesenchymal invasion of cancer cells at the primary site but not at the metastatic site. Depletion of NEDD9 is sufficient to suppress invasion of tumor cells in vitro and in vivo, leading to decreased circulating tumor cel

SUBMITTER: McLaughlin SL 

PROVIDER: S-EPMC3946989 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature