Breast cancer subtypes and previously established genetic risk factors: a bayesian approach.

ABSTRACT:

Background

Gene expression analyses indicate that breast cancer is a heterogeneous disease with at least five immunohistologic subtypes. Despite growing evidence that these subtypes are etiologically and prognostically distinct, few studies have investigated whether they have divergent genetic risk factors. To help fill in this gap in our understanding, we examined associations between breast cancer subtypes and previously established susceptibility loci among white and African-American women in the Carolina Breast Cancer Study.

Methods

We used Bayesian polytomous logistic regression to estimate ORs and 95% posterior intervals for the association between each of 78 single nucleotide polymorphisms (SNP) and five breast cancer subtypes. Subtypes were defined using five immunoh

SUBMITTER: O'Brien KM 

PROVIDER: S-EPMC3947131 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature