Cognitive and motor function in long-duration PARKIN-associated Parkinson disease.

ABSTRACT:

Importance

Data on the long-term cognitive outcomes of patients with PARKIN-associated Parkinson disease (PD) are unknown but may be useful when counseling these patients.

Objective

Among patients with early-onset PD of long duration, we assessed cognitive and motor performances, comparing homozygotes and compound heterozygotes who carry 2 PARKIN mutations with noncarriers.

Design, setting, and participants

Cross-sectional study of 44 participants at 17 different movement disorder centers who were in the Consortium on Risk for Early-Onset PD study with a duration of PD greater than the median duration (>14 years): 4 homozygotes and 17 compound heterozygotes (hereafter referred to as carriers) and 23 noncarriers.

Main outcomes and measures

Unified Parkinson Dise

SUBMITTER: Alcalay RN 

PROVIDER: S-EPMC3947132 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature