Genes-environment interactions in obesity- and diabetes-associated pancreatic cancer: a GWAS data analysis.

ABSTRACT:

Background

Obesity and diabetes are potentially alterable risk factors for pancreatic cancer. Genetic factors that modify the associations of obesity and diabetes with pancreatic cancer have previously not been examined at the genome-wide level.

Methods

Using genome-wide association studies (GWAS) genotype and risk factor data from the Pancreatic Cancer Case Control Consortium, we conducted a discovery study of 2,028 cases and 2,109 controls to examine gene-obesity and gene-diabetes interactions in relation to pancreatic cancer risk by using the likelihood-ratio test nested in logistic regression models and Ingenuity Pathway Analysis (IPA).

Results

After adjusting for multiple comparisons, a significant interaction of the chemokine signaling pathway with obesity (P =

SUBMITTER: Tang H 

PROVIDER: S-EPMC3947145 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature