Obligatory roles of filamin A in E-cadherin-mediated cell-cell adhesion in epidermal keratinocytes.

ABSTRACT:

Background

Extracellular Ca(2+) (Cao(2+))-induced E-cadherin-mediated cell-cell adhesion plays a critical role in promoting differentiation in epidermal keratinocytes. Our previous studies show that the calcium-sensing receptor (CaR) regulates keratinocyte cell-cell adhesion and differentiation via Rho A-mediated signaling. CaR forms a protein complex with Rho A, guanine nucleotide exchange factor Trio, and a cytoskeletal actin-binding protein, filamin A, at the cell-cell junctions in response to elevated Cao(2+) levels. Filamin A has the ability to interact directly with CaR, Trio, and Rho and mediate CaR-dependent signaling events.

Objective

This study was conducted to investigate the roles of filamin A and Trio in regulating Cao(2+)-induced Rho activation and intercellula

SUBMITTER: Tu CL 

PROVIDER: S-EPMC3947258 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature