Defects of the lamina cribrosa in eyes with localized retinal nerve fiber layer loss.

ABSTRACT:

Objective

To determine whether focal abnormalities of the lamina cribrosa (LC) are present in glaucomatous eyes with localized retinal nerve fiber layer (RNFL) defects.

Design

Cross-sectional, observational study.

Participants

We analyzed 20 eyes of 14 subjects with localized RNFL defects detected by masked grading of stereophotographs and 40 eyes of 25 age-matched healthy subjects recruited from the Diagnostic Innovations in Glaucoma Study at the University of California, San Diego.

Methods

All eyes had stereoscopic optic disc photography and in vivo LC imaging using enhanced depth imaging optical coherence tomography (EDI-OCT). Two masked graders identified focal LC defects defined by a standardized protocol using 48 radial scan EDI-OCT images. The kappa coef

SUBMITTER: Tatham AJ 

PROVIDER: S-EPMC3947348 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature