Candidate gene approach to identifying rare genetic variants associated with lone atrial fibrillation.

ABSTRACT:

Background

Rare variants in candidate atrial fibrillation (AF) genes have been associated with AF in small kindreds. The extent to which such polymorphisms contribute to AF is unknown.

Objective

The purpose of this study was to determine the spectrum and prevalence of rare amino acid coding (AAC) variants in candidate AF genes in a large cohort of unrelated lone AF probands.

Methods

We resequenced 45 candidate genes in 303 European American (EA) lone AF probands (186 lone AF probands screened for each gene on average [range 89-303], 63 screened for all) identified in the Vanderbilt AF Registry (2002-2012). Variants detected were screened against 4300 EAs from the Exome Sequencing Project (ESP) to identify very rare (minor allele frequency ≤0.04%) AAC variants and thes

SUBMITTER: Weeke P 

PROVIDER: S-EPMC3947369 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature