Relationship between systemic cytokines and complement factor H Y402H polymorphism in patients with dry age-related macular degeneration.

ABSTRACT:

Purpose

To investigate the relationship between systemic cytokines, the complement factor H (CFH) Y402H polymorphism, drusen load, and subfoveal choroidal thickness in patients with dry age-related macular degeneration (AMD).

Design

Cross-sectional study.

Methods

Forty-four dry AMD patients under care of the Retina Service at the University of British Columbia were enrolled. Drusen load was measured with an automated software algorithm in spectral-domain optical coherence tomography; subfoveal choroidal thickness was measured manually using enhanced depth imaging. Bio-Plex suspension assays (Bio-Rad Laboratories) were used to analyze cytokines in plasma and CFH Y402H was genotyped. Statistical analyses included analysis of covariance and Pearson correlation, corrected

SUBMITTER: Cao S 

PROVIDER: S-EPMC3947379 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature