Inflammatory markers and development of symptom burden in patients with multiple myeloma during autologous stem cell transplantation.

ABSTRACT:

Purpose

Increasing research suggests that inflammation mediates symptom development. In this longitudinal study, we examined inflammatory factors related to the development of high symptom burden during autologous hematopoietic stem cell transplant (AuSCT) for multiple myeloma.

Experimental design

Patients (n = 63) repeatedly reported symptom severity on the MD Anderson Symptom Inventory multiple myeloma module (MDASI-MM) and contributed blood samples periodically for up to 100 days after AuSCT for inflammatory marker assays. The temporal associations between serum inflammatory marker concentrations and symptom severity outcomes were examined by nonlinear mixed-effect modeling.

Results

Fatigue, pain, disturbed sleep, lack of appetite, and drowsiness were consistently

SUBMITTER: Wang XS 

PROVIDER: S-EPMC3947467 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature