Cell migration driven by cooperative substrate deformation patterns.

ABSTRACT: Most eukaryotic cells sense and respond to the mechanical properties of their surroundings. This can strongly influence their collective behavior in embryonic development, tissue function, and wound healing. We use a deformable substrate to measure collective behavior in cell motion due to substrate mediated cell-cell interactions. We quantify spatial and temporal correlations in migration velocity and substrate deformation, and show that cooperative cell-driven patterns of substrate deformation mediate long-distance mechanical coupling between cells and control collective cell migration.

SUBMITTER: Angelini TE 

PROVIDER: S-EPMC3947506 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature