Genetic, transcriptomic, and epigenetic studies of HIV-associated neurocognitive disorder.

ABSTRACT: The Human Genome Project, coupled with rapidly evolving high-throughput technologies, has opened the possibility of identifying heretofore unknown biological processes underlying human disease. Because of the opaque nature of HIV-associated neurocognitive disorder (HAND) neuropathogenesis, the utility of such methods has gained notice among NeuroAIDS researchers. Furthermore, the merging of genetics with other research areas has also allowed for application of relatively nascent fields, such as neuroimaging genomics, and pharmacogenetics, to the context of HAND. In this review, we detail the development of genetic, transcriptomic, and epigenetic studies of HAND, beginning with early candidate gene association studies and culminating in current "omics" approaches that incorporate methods fr

SUBMITTER: Levine AJ 

PROVIDER: S-EPMC3947559 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature