Challenges in elucidating the genetics of diabetic retinopathy.

ABSTRACT:

Importance

In the past decade, significant progress in genomic medicine and technologic developments has revolutionized our approach to common complex disorders in many areas of medicine, including ophthalmology. A disorder that still needs major genetic progress is diabetic retinopathy (DR), one of the leading causes of blindness in adults.

Objective

To perform a literature review, present the current findings, and highlight some key challenges in DR genetics.

Design, setting, and participants

We performed a thorough literature review of the genetic factors for DR, including heritability scores, twin studies, family studies, candidate gene studies, linkage studies, and genome-wide association studies (GWASs).

Main outcome measures

Environmental and genetic fac

SUBMITTER: Kuo JZ 

PROVIDER: S-EPMC3947937 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature