Impaired lipid and glucose homeostasis in hexabromocyclododecane-exposed mice fed a high-fat diet.

ABSTRACT:

Background

Hexabromocyclododecane (HBCD) is an additive flame retardant used in the textile industry and in polystyrene foam manufacturing. Because of its lipophilicity and persistency, HBCD accumulates in adipose tissue and thus has the potential of causing metabolic disorders through disruption of lipid and glucose homeostasis. However, the association between HBCD and obesity remains unclear.

Objectives

We investigated whether exposure to HBCD contributes to initiation and progression of obesity and related metabolic dysfunction in mice fed a normal diet (ND) or a high-fat diet (HFD).

Methods

Male C57BL/6J mice were fed a HFD (62.2 kcal% fat) or a ND and treated orally with HBCD (0, 1.75, 35, or 700 μg/kg body weight) weekly from 6 to 20 weeks of age. We examined b

SUBMITTER: Yanagisawa R 

PROVIDER: S-EPMC3948039 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature