Relative influence of heritability, environment and genetics on serum sclerostin.

ABSTRACT:

Summary

We determined factors associated with serum sclerostin in 446 Afro-Caribbean family members. Age, weight, sex, diabetes and kidney function were associated with sclerostin. Sclerostin was heritable, and nine SNPs in the SOST gene region were associated with sclerostin. Variation in serum sclerostin is a heritable factor that is determined by both genetic and environmental factors.

Introduction

Sclerostin, encoded by the SOST gene, is a Wnt inhibitor that regulates bone mineralization and is a candidate gene locus for osteoporosis. However, little is known about the genetic and non-genetic sources of inter-individual variation in serum sclerostin levels.

Methods

Serum sclerostin was measured in 446 Afro-Caribbean men and women aged 18+ from seven large, multige

SUBMITTER: Kuipers AL 

PROVIDER: S-EPMC3948173 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature