Chromosome 3p loss of heterozygosity is associated with a unique metabolic network in clear cell renal carcinoma.

ABSTRACT: Several common oncogenic pathways have been implicated in the emergence of renowned metabolic features in cancer, which in turn are deemed essential for cancer proliferation and survival. However, the extent to which different cancers coordinate their metabolism to meet these requirements is largely unexplored. Here we show that even in the heterogeneity of metabolic regulation a distinct signature encompassed most cancers. On the other hand, clear cell renal cell carcinoma (ccRCC) strongly deviated in terms of metabolic gene expression changes, showing widespread down-regulation. We observed a metabolic shift that associates differential regulation of enzymes in one-carbon metabolism with high tumor stage and poor clinical outcome. A significant yet limited set of metabolic genes that exp

SUBMITTER: Gatto F 

PROVIDER: S-EPMC3948310 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature