Annual FEV1 changes and numbers of circulating endothelial microparticles in patients with COPD: a prospective study.

ABSTRACT:

Objective

Growing evidence suggests that endothelial injury is involved in the pathophysiology of chronic obstructive pulmonary disease (COPD). Circulating endothelial microparticles (EMPs) increase in patients with COPD because of the presence of endothelial injury. We examined the relationship between EMP number and changes in forced expiratory volume in 1 s (FEV1) in patients with COPD.

Design

Prospective study.

Setting

One hospital in Japan.

Participants

A total 48 outpatients with stable COPD coming to the hospital from September 2010 to September 2011.

Primary and secondary outcomes measured

Blood samples were collected and vascular endothelial (VE)-cadherin EMPs (CD144+ EMPs), E-selectin EMPs (CD62E+ EMPs) and platelet endothelial cell adhesion mo

SUBMITTER: Takahashi T 

PROVIDER: S-EPMC3948576 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature