Association between six genetic polymorphisms and colorectal cancer: a meta-analysis.

ABSTRACT:

Objective

The aim of this study was to determine whether six genetic polymorphisms confer susceptibility to colorectal cancer (CRC).

Methods

A systematic search for candidate genes of CRC was performed among several online databases, including PubMed, Embase, Web of Science, the Cochrane Library, CNKI, and Wanfang online libraries. After a comprehensive filtering procedure, we harvested five genes, including MGMT (rs12917 and rs2308321), ADH1B (rs1229984), SOD2 (rs4880), XPC (rs2228001), and PPARG (rs1801282). Using the REVMAN and Stata software, six meta-analyses were conducted for associations between CRC and the just-mentioned genetic variants.

Results

A total of 34 comparative studies among 17,289 cases and 54,927 controls were involved in our meta-analyses. Signi

SUBMITTER: Chen C 

PROVIDER: S-EPMC3948603 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature