Association of autoimmune Addison's disease with alleles of STAT4 and GATA3 in European cohorts.

ABSTRACT:

Background

Gene variants known to contribute to Autoimmune Addison's disease (AAD) susceptibility include those at the MHC, MICA, CIITA, CTLA4, PTPN22, CYP27B1, NLRP-1 and CD274 loci. The majority of the genetic component to disease susceptibility has yet to be accounted for.

Aim

To investigate the role of 19 candidate genes in AAD susceptibility in six European case-control cohorts.

Methods

A sequential association study design was employed with genotyping using Sequenom iPlex technology. In phase one, 85 SNPs in 19 genes were genotyped in UK and Norwegian AAD cohorts (691 AAD, 715 controls). In phase two, 21 SNPs in 11 genes were genotyped in German, Swedish, Italian and Polish cohorts (1264 AAD, 1221 controls). In phase three, to explore association of GATA3 polymo

SUBMITTER: Mitchell AL 

PROVIDER: S-EPMC3948621 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature