Optogenetic stimulation in a computational model of the basal ganglia biases action selection and reward prediction error.

ABSTRACT: Optogenetic stimulation of specific types of medium spiny neurons (MSNs) in the striatum has been shown to bias the selection of mice in a two choices task. This shift is dependent on the localisation and on the intensity of the stimulation but also on the recent reward history. We have implemented a way to simulate this increased activity produced by the optical flash in our computational model of the basal ganglia (BG). This abstract model features the direct and indirect pathways commonly described in biology, and a reward prediction pathway (RP). The framework is similar to Actor-Critic methods and to the ventral/dorsal distinction in the striatum. We thus investigated the impact on the selection caused by an added stimulation in each of the three pathways. We were able to reproduce in

SUBMITTER: Berthet P 

PROVIDER: S-EPMC3948624 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature