Meconium microbiome analysis identifies bacteria correlated with premature birth.

ABSTRACT:

Background

Preterm birth is the second leading cause of death in children under the age of five years worldwide, but the etiology of many cases remains enigmatic. The dogma that the fetus resides in a sterile environment is being challenged by recent findings and the question has arisen whether microbes that colonize the fetus may be related to preterm birth. It has been posited that meconium reflects the in-utero microbial environment. In this study, correlations between fetal intestinal bacteria from meconium and gestational age were examined in order to suggest underlying mechanisms that may contribute to preterm birth.

Methods

Meconium from 52 infants ranging in gestational age from 23 to 41 weeks was collected, the DNA extracted, and 16S rRNA analysis performed. Resulti

SUBMITTER: Ardissone AN 

PROVIDER: S-EPMC3948723 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature