E2 proteins of high risk human papillomaviruses down-modulate STING and IFN-κ transcription in keratinocytes.

ABSTRACT: In the early stages of human papillomavirus (HPV) infection, the viral proteins elicit specific immune responses that can participate to regression of ano-genital lesions. HPV E6 protein for instance can reduce type I interferon (IFN) including IFN-κ that is involved in immune evasion and HPV persistence. To evaluate the role of E2 protein in innate immunity in HPV16-associated cervical lesions, genome-wide expression profiling of human primary keratinocytes (HPK) transduced by HPV16 E2 was investigated using microarrays and innate immunity associated genes were specifically analyzed. The analyses showed that the expression of 779 genes was modulated by HPV16E2 and 92 of them were genes associated with innate immunity. Notably IFN-κ and STING were suppressed in HPK expressing the E2 protei

SUBMITTER: Sunthamala N 

PROVIDER: S-EPMC3948877 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature