Retinoic acid induces changes in electrical properties of adult neurons in a dose- and isomer-dependent manner.

ABSTRACT: The electrical activity of neurons is known to play a role in neuronal development, as well as repair of adult nervous tissue. For example, the extension of neurites and motility of growth cones can be modulated by changes in the electrical firing of neurons. The vitamin A metabolite retinoic acid also plays a critical role during nervous system development and is also known to elicit regenerative responses, namely the induction, enhancement, and directionality of neurite outgrowth. However, no studies have previously reported the ability of retinoic acid to modify the electrical activity of neurons. In this study, we determined whether retinoic acid might exert effects on the nervous system by altering the electrical properties of neurons. Using cultured adult neurons from Lymnaea stagnal

SUBMITTER: Vesprini ND 

PROVIDER: S-EPMC3949307 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature