In silico study of ligand binding site of toll-like receptor 5.

ABSTRACT:

Background

Toll-like receptor-5 (TLR-5) is a member of TLRs family and responsible for bacterial flagellin recognition. The activation of TLR-5 with flagellin leads to initiation of signaling cascades, which in turn results in transcription of pro-inflammatory cytokines. Regarding the critical role of TLR-5 agonists and antagonists in activation of innate immune responses, an increasing number of studies have focused on their therapeutic applications in drug and vaccine design. In this study, to identify the most critical region and residues of TLR-5 for interaction with flagellin, different truncated forms of TLR-5 were designed and subjected to protein-protein interaction studies.

Materials and methods

The interactions of the full native TLR-5 and its truncated forms with

SUBMITTER: Savar NS 

PROVIDER: S-EPMC3949343 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature