Multi-PAS domain-mediated protein oligomerization of PpsR from Rhodobacter sphaeroides.

ABSTRACT: Per-ARNT-Sim (PAS) domains are essential modules of many multi-domain signalling proteins that mediate protein interaction and/or sense environmental stimuli. Frequently, multiple PAS domains are present within single polypeptide chains, where their interplay is required for protein function. Although many isolated PAS domain structures have been reported over the last decades, only a few structures of multi-PAS proteins are known. Therefore, the molecular mechanism of multi-PAS domain-mediated protein oligomerization and function is poorly understood. The transcription factor PpsR from Rhodobacter sphaeroides is such a multi-PAS domain protein that, in addition to its three PAS domains, contains a glutamine-rich linker and a C-terminal helix-turn-helix DNA-binding motif. Here, crystal str

SUBMITTER: Heintz U 

PROVIDER: S-EPMC3949515 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature