Structure of the extended-spectrum class C β-lactamase ADC-1 from Acinetobacter baumannii.

ABSTRACT: ADC-type class C β-lactamases comprise a large group of enzymes that are encoded by genes located on the chromosome of Acinetobacter baumannii, a causative agent of serious bacterial infections. Overexpression of these enzymes renders A. baumannii resistant to various β-lactam antibiotics and thus severely compromises the ability to treat infections caused by this deadly pathogen. Here, the high-resolution crystal structure of ADC-1, the first member of this clinically important family of antibiotic-resistant enzymes, is reported. Unlike the narrow-spectrum class C β-lactamases, ADC-1 is capable of producing resistance to the expanded-spectrum cephalosporins, rendering them inactive against A. baumannii. The extension of the substrate profile of the enzyme is likely to be the result of str

SUBMITTER: Bhattacharya M 

PROVIDER: S-EPMC3949520 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature