Shape information in repeated glucose curves during pregnancy provided significant physiological information for neonatal outcomes.

ABSTRACT:

Objective

To use multilevel functional principal component analysis to exploit the information inherent in the shape of longitudinally sampled glucose curves during pregnancy, and to analyse the impact of glucose curve characteristics on neonatal birth weight, percentage fat and cord blood C-peptide.

Study design and setting

A cohort study of healthy, pregnant women (n = 884). They underwent two oral glucose tolerance tests (gestational weeks 14-16 and 30-32), which gave two glucose curves per woman.

Results

Glucose values were higher, and peaked later in third trimester than in early pregnancy. The curve characteristic "general glucose level" accounted for 91% of the variation across visits, and 72% within visits. The curve characteristics "timing of postprandial pea

SUBMITTER: Froslie KF 

PROVIDER: S-EPMC3949679 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature