Response of the primary auditory and non-auditory cortices to acoustic stimulation: a manganese-enhanced MRI study.

ABSTRACT: Structural and functional features of various cerebral cortices have been extensively explored in neuroscience research. We used manganese-enhanced MRI, a non-invasive method for examining stimulus-dependent activity in the whole brain, to investigate the activity in the layers of primary cortices and sensory, such as auditory and olfactory, pathways under acoustic stimulation. Male Sprague-Dawley rats, either with or without exposure to auditory stimulation, were scanned before and 24-29 hour after systemic MnCl2 injection. Cortex linearization and layer-dependent signal extraction were subsequently performed for detecting layer-specific cortical activity. We found stimulus-dependent activity in the deep layers of the primary auditory cortex and the auditory pathways. The primary sensory

SUBMITTER: Kim H 

PROVIDER: S-EPMC3949704 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature