Nicotine patches in pregnant smokers: randomised, placebo controlled, multicentre trial of efficacy.

ABSTRACT:

Objective

To determine the efficacy of 16 hour nicotine patches among pregnant smokers, with the dose individually adjusted according to saliva cotinine levels (potential range 10-30 mg/day).

Design

Randomised, double blind, placebo controlled, parallel group, multicentre trial (Study of Nicotine Patch in Pregnancy, SNIPP) between October 2007 and January 2013.

Setting

23 maternity wards in France.

Participants

476 pregnant smokers aged more than 18 years and between 12 and 20 weeks' gestation, who smoked at least five cigarettes a day. After exclusions, 402 women were randomised: 203 to nicotine patches and 199 to placebo patches. Data were available on 192 live births in each group.

Interventions

Nicotine and identical placebo patches were administered

SUBMITTER: Berlin I 

PROVIDER: S-EPMC3950302 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature