Delayed innocent bystander cell death following hypoxia in Caenorhabditis elegans.

ABSTRACT: After hypoxia, cells may die immediately or have a protracted course, living or dying depending on an incompletely understood set of cell autonomous and nonautonomous factors. In stroke, for example, some neurons are thought to die from direct hypoxic injury by cell autonomous primary mechanisms, whereas other so called innocent bystander neurons die from factors released from the primarily injured cells. A major limitation in identifying these factors is the inability of current in vivo models to selectively target a set of cells for hypoxic injury so that the primarily injured cells and the innocent bystanders are clearly delineated. In order to develop such a model, we generated transgenic Caenorhabditis elegans strains where 2-3% of somatic cells were made selectively sensitive to hypo

SUBMITTER: Sun CL 

PROVIDER: S-EPMC3950319 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature