The fate of inhaled (14)C-labeled PCB11 and its metabolites in vivo.

ABSTRACT:

Background

The production ban of polychlorinated biphenyl (PCB) technical mixtures has left the erroneous impression that PCBs exist only as legacy pollutants. Some lower-chlorinated PCBs are still being produced and contaminate both indoor and ambient air.

Objectives

To inform PCB risk assessment, we characterized lung uptake, distribution, metabolism and excretion of PCB11 as a signature compound for these airborne non-legacy PCBs.

Methods

After delivering [(14)C]PCB11 to the lungs of male rats, radioactivity in 34 major tissues and 5 digestive matter compartments was measured at 12, 25, 50, 100, 200 and 720min postexposure, during which time the excreta and exhaled air were also collected. [(14)C]PCB11 and metabolites in lung, liver, blood, digestive matter, urine,

SUBMITTER: Hu X 

PROVIDER: S-EPMC3950335 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature