The behavior of neuronal cells on tendon-derived collagen sheets as potential substrates for nerve regeneration.

ABSTRACT: Peripheral nervous system injuries result in a decreased quality of life, and generally require surgical intervention for repair. Currently, the gold standard of nerve autografting, based on the use of host tissue such as sensory nerves is suboptimal as it results in donor-site loss of function and requires a secondary surgery. Nerve guidance conduits fabricated from natural polymers such as collagen are a common alternative to bridge nerve defects. In the present work, tendon sections derived through a process named bioskiving were studied for their potential for use as a substrate to fabricate nerve guidance conduits. We show that cells such as rat Schwann cells adhere, proliferate, and align along the fibrous tendon substrate which has been shown to result in a more mature phenotype. Ad

SUBMITTER: Alberti KA 

PROVIDER: S-EPMC3950350 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature