Pulmonary rehabilitation: the reference therapy for undernourished patients with chronic obstructive pulmonary disease.

ABSTRACT: Chronic obstructive pulmonary disease (COPD) combines the deleterious effects of chronic hypoxia, chronic inflammation, insulin-resistance, increased energy expenditure, muscle wasting, and exercise deconditioning. As for other chronic disorders, loss of fat-free mass decreased survival. The preservation of muscle mass and function, through the protection of the mitochondrial oxidative metabolism, is an important challenge in the management of COPD patients. As the prevalence of the disease is increasing and the medical advances make COPD patients live longer, the prevalence of COPD-associated nutritional disorders is expected to increase in future decades. Androgenopenia is observed in 40% of COPD patients. Due to the stimulating effects of androgens on muscle anabolism, androgenopenia fa

SUBMITTER: Samaras N 

PROVIDER: S-EPMC3950477 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature