Archaeal genome guardians give insights into eukaryotic DNA replication and damage response proteins.

ABSTRACT: As the third domain of life, archaea, like the eukarya and bacteria, must have robust DNA replication and repair complexes to ensure genome fidelity. Archaea moreover display a breadth of unique habitats and characteristics, and structural biologists increasingly appreciate these features. As archaea include extremophiles that can withstand diverse environmental stresses, they provide fundamental systems for understanding enzymes and pathways critical to genome integrity and stress responses. Such archaeal extremophiles provide critical data on the periodic table for life as well as on the biochemical, geochemical, and physical limitations to adaptive strategies allowing organisms to thrive under environmental stress relevant to determining the boundaries for life as we know it. Specifical

SUBMITTER: Shin DS 

PROVIDER: S-EPMC3950489 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature