Computational analysis reveals a correlation of exon-skipping events with splicing, transcription and epigenetic factors.

ABSTRACT: Alternative splicing (AS), in higher eukaryotes, is one of the mechanisms of post-transcriptional regulation that generate multiple transcripts from the same gene. One particular mode of AS is the skipping event where an exon may be alternatively excluded or constitutively included in the resulting mature mRNA. Both transcript isoforms from this skipping event site, i.e. in which the exon is either included (inclusion isoform) or excluded (skipping isoform), are typically present in one cell, and maintain a subtle balance that is vital to cellular function and dynamics. However, how the prevailing conditions dictate which isoform is expressed and what biological factors might influence the regulation of this process remain areas requiring further exploration. In this study, we have develop

SUBMITTER: Ye Z 

PROVIDER: S-EPMC3950716 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature