Molecular heterogeneity and prognostic implications of synchronous advanced colorectal neoplasia.

ABSTRACT:

Background

It is uncertain whether synchronous colorectal cancers (S-CRCs) preferentially develop through widespread DNA methylation and whether they have a prognosis worse than solitary CRC. As tumours with microsatellite instability (MSI) may confound the effect of S-CRC methylation on outcome, we addressed this issue in a series of CRC characterised by BRAF and MS status.

Methods

Demographics, clinicopathological records and disease-specific survival (DSS) were assessed in 881 consecutively resected CRC undergoing complete colonoscopy. All tumours were typed for BRAF(c.1799T>A) mutation and MS status, followed by search of germ-line mutation in patients with MSI CRC.

Results

Synchronous colorectal cancers (50/881, 5.7%) were associated with stage IV microsatellite-

SUBMITTER: Malesci A 

PROVIDER: S-EPMC3950856 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature