Inhibition of CXCR7 extends survival following irradiation of brain tumours in mice and rats.

ABSTRACT:

Background

In experimental models of glioblastoma multiforme (GBM), irradiation (IR) induces local expression of the chemokine CXCL12/SDF-1, which promotes tumour recurrence. The role of CXCR7, the high-affinity receptor for CXCL12, in the tumour's response to IR has not been addressed.

Methods

We tested CXCR7 inhibitors for their effects on tumour growth and/or animal survival post IR in three rodent GBM models. We used immunohistochemistry to determine where CXCR7 protein is expressed in the tumours and in human GBM samples. We used neurosphere formation assays with human GBM xenografts to determine whether CXCR7 is required for cancer stem cell (CSC) activity in vitro.

Results

CXCR7 was detected on tumour cells and/or tumour-associated vasculature in the rodent mod

SUBMITTER: Walters MJ 

PROVIDER: S-EPMC3950859 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature