Probability of cancer in pulmonary nodules detected on first screening CT.

ABSTRACT:

Background

Major issues in the implementation of screening for lung cancer by means of low-dose computed tomography (CT) are the definition of a positive result and the management of lung nodules detected on the scans. We conducted a population-based prospective study to determine factors predicting the probability that lung nodules detected on the first screening low-dose CT scans are malignant or will be found to be malignant on follow-up.

Methods

We analyzed data from two cohorts of participants undergoing low-dose CT screening. The development data set included participants in the Pan-Canadian Early Detection of Lung Cancer Study (PanCan). The validation data set included participants involved in chemoprevention trials at the British Columbia Cancer Agency (BCCA), sponso

SUBMITTER: McWilliams A 

PROVIDER: S-EPMC3951177 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature