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Simple, chemoselective hydrogenation with thermodynamic stereocontrol.

ABSTRACT: Few methods permit the hydrogenation of alkenes to a thermodynamically favored configuration when steric effects dictate the alternative trajectory of hydrogen delivery. Dissolving metal reduction achieves this control, but with extremely low functional group tolerance. Here we demonstrate a catalytic hydrogenation of alkenes that affords the thermodynamic alkane products with remarkably broad functional group compatibility and rapid reaction rates at standard temperature and pressure.

SUBMITTER: Iwasaki K

PROVIDER: S-EPMC3951266 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature

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Simple, chemoselective hydrogenation with thermodynamic stereocontrol.

Iwasaki Kotaro K Wan Kanny K KK Oppedisano Alberto A Crossley Steven W M SW Shenvi Ryan A RA

Journal of the American Chemical Society 20140115 4

Few methods permit the hydrogenation of alkenes to a thermodynamically favored configuration when steric effects dictate the alternative trajectory of hydrogen delivery. Dissolving metal reduction achieves this control, but with extremely low functional group tolerance. Here we demonstrate a catalytic hydrogenation of alkenes that affords the thermodynamic alkane products with remarkably broad functional group compatibility and rapid reaction rates at standard temperature and pressure. ...[more]

PMID: 24428640

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